引用本文:刘怡然,刘西茹,漆洪波.孕前和孕早期叶酸补充与双胎妊娠率的Meta分析[J].重庆医科大学学报,2013,(10):1121~1124
孕前和孕早期叶酸补充与双胎妊娠率的Meta分析
Effects of periconceptional folic acid supplementation on incidences of twin pregnancy:a Meta analysis
DOI:
中文关键词:  叶酸补充  双胎妊娠  Meta分析
英文关键词:folic acid supplementation  twin pregnancy  Meta analysis
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作者单位
刘怡然,刘西茹,漆洪波 重庆医科大学附属第一医院妇产科重庆 400016 
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中文摘要:
      目的:本文旨在系统评价孕前和孕早期补充叶酸对双胎妊娠的作用。方法:系统收集1966-2012年来自PubMed/Med-line、EMBASE、OVID、Cochrane Central Register of Clinical Trials、Google Scholarism、CNKI、维普、万方数据库关于孕前和孕早期补充叶酸的相关文献,并根据预先制定的纳入与排除标准筛选文献,严格评价纳入文献质量,提取数据,RevMan 5.2.1软件进行Meta分析。结果:纳入3篇随机对照试验,Meta分析结果示孕前和孕早期补充叶酸与未补充相比双胎妊娠率(RR=1.40,95%CI=0.93~2.11),双卵双生率(RR=1.27,95%CI=0.61~2.67)与单卵双生率(RR=0.91,95%CI=0.68~1.21)的差异均无统计学意义。结论:孕前和孕早期补充叶酸与未补充相比,没有提高双胎妊娠率。
英文摘要:
      Objective:To use Meta analysis to assess the effects of folic acid supplementation before and during early pregnancy on twin pregnancy. Methods:Literatures associated with periconceptional folic acid supplementation between 1966 and 2012 were col-lected systematically from PubMed/Medline,EMBASE,OVID,Cochrane Central Register of Clinical Trials,Google scholarism,CNKI,VIP,Wanfang databases,then were screened according to the pre-established inclusion and exclusion standards. Quality was evaluat-ed strictly. Data were extracted and Meta analysis was conducted using RevMan 5.2.1 software. Results:Three randomized controlled trials(RCTs) were included. Differences in twin pregnancy incidences(RR=1.40,95%CI=0.93 to 2.11),dizygotic incidences(RR=1.27,95%CI=0.61 to 2.67) and monozygotic incidences(RR=0.91,95%CI=0.68 to 1.21) were of no statistically significant between group with folic acid supplementation before and during early pregnancy and control group. Conclusion:Folic acid supplementation before and during early pregnancy can not increase incidences of twin pregnancy.
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