引用本文:张格祥,王蕾蕾,董继元,魏学艳,丁杰超.三氯生对孕鼠妊娠结局的影响及机理[J].重庆医科大学学报,2013,(10):1163~1167
三氯生对孕鼠妊娠结局的影响及机理
Effects of triclosan on pregnancy outcome in pregnant rats and its mechanism
DOI:
中文关键词:  三氯生  活胎  死胎  吸收胎  抗氧化水平
英文关键词:triclosan  live fetus  dead fetus  absorbed fetus  antioxidant level
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张格祥,王蕾蕾,董继元,魏学艳,丁杰超 兰州大学公共卫生学院营养与食品卫生研究所兰州 730000 
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中文摘要:
      目的:明确三氯生对孕鼠妊娠结局的影响及初步探讨其相关机制,为指导人群特别是孕妇合理选择与使用三氯生类洗涤用品提供科学参考。方法:将 32 只妊娠 Wistar大鼠随机分为 4 组,溶剂对照(花生油)组和低[30 mg/(kg·d)]、中[100 mg/(kg·d)]、高[300 mg/(kg·d)]剂量组,妊娠 6~20 d连续灌胃给予相应受试物,孕 20 d处死,记录孕鼠各脏器系数,观察活胎数、死胎数、吸收胎数,采血测生化、血糖等。结果:各组孕鼠体质量、进食量及食物利用率总体随妊娠孕期增加,高剂量组大鼠孕中期体质量、进食量及食物利用率增加幅度较溶剂对照组小(P<0.05),重复测量方差分析显示,不同孕期孕鼠体质量、进食量及食物利用率在各组之间均不同(P<0.05),且体质量的时间因素和处理因素间存在交互作用(P<0.01)。高剂量组孕鼠空腹血糖组内差异有显著性(P<0.05),重复测量方差分析结果显示,不同孕期孕鼠的血糖在各组之间不同(P<0.05),但时间因素与处理因素之间无交互作用。高剂量组孕鼠血清丙二醛水平和总蛋白与溶剂对照组比较有统计学意义(P<0.05),其余指标变化不明显。高剂量组孕鼠活胎构成低于溶剂对照组,吸收胎构成高于溶剂对照组,但差异无统计学意义(P >0.05)。结论:长期大量接触或使用含三氯生的产品,可能会造成机体本身生化指标及血糖水平等的改变,建议人群日常生活中正确选用护理产品,尤其是怀孕的妇女。三氯生可能会影响机体的消化功能和能量物质代谢等,进一步影响胎儿骨骼和脑组织的正常生长发育,建议孕妇慎用含三氯生的产品。
英文摘要:
      Objective:To determine the influences of triclosan on pregnancy outcome in pregnant rats,to preliminarily study its related mechanism and to provide scientific references for rational use of washing supplies containing triclosan,especially for pregnant wom-en. Methods:Totally 32 pregnant Wistar rats were randomly divided into 4 groups(control group,low dose group,middle dose group and high dose group)and received triclosan by oral gavage(0,30,100,300) mg/(kg·d) in peanut oil for 15 d consecutively from ges-tational day(GD) 6 to GD 20 until necropsy on GD 20. Coefficient of each body organ,number of live fetus,dead fetus and absorbed fetus,biochemistry indicators and blood glucose were recoded. Results:Body weight,food intake and food utilization rate were increased along with the increase of pregnancy. But the increases were higher in high dose group than in control group in the second trimester of pregnancy(P<0.05). ANOVA for repeated measurement demonstrated that body weight,food intake and food utilization rate were different at different periods of pregnancy among four groups(P<0.05),meanwhile,time factor and processing factor of body weight were interacted(P<0.01). Fasting plasma glucose levels in high dose group were different within groups(P<0.05). ANOVA for repeated measurement demonstrated blood glucose levels were different at different periods of pregnancy among groups(P<0.05),meanwhile,time factor and processing factor of body weight were not interacted. Levels of serum methane dicarboxylic aldehyde and total protein were significantly different between high dose group and control group(P<0.05). Live fetus was more in control group than in high dose group;absorbed fetus was more in high dose group than in control group,without statistical differences. Conclusions:Using a large number of triclosan products may change blood glucose and biochemistry indexes,therefore people should be cautious when choosing personal care products,especially pregnancy women. Triclosan may affect the digestion and energy metabolism of pregnancy women,further influence normal development of fetal brains and bones,so pregnancy women should use triclosan products carefully.
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