引用本文:何 东,李骊华.Cox-2及Salusin-a在急性冠脉综合征危险分层的预测价值[J].重庆医科大学学报,2014,38(1):69~72
Cox-2及Salusin-a在急性冠脉综合征危险分层的预测价值
Predictive value of Cox-2 and Salusin-a in the risk stratification of acute coronary syndrome
DOI:
中文关键词:  急性冠脉综合征  Cox-2  超敏C反应蛋白  Salusin-a
英文关键词:acute coronary syndrome  Cox-2  high sensitivity-C reactive protein  Salusin-a
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何 东,李骊华 重庆医科大学附属第一医院心血管内科重庆 400016 
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中文摘要:
      目的:探讨炎症因子 Cox-2及脂质因子Salusin-a对急性冠脉综合征(acute coronary sydrome,ACS)危险分层的预测价值及与主要危险因素的相关性。方法:入选110例行冠脉造影患者,根据患者的病史及冠脉造影结果分为3组:ACS组61例、稳定性心绞痛(stable angina pectoris,SAP)组19例、冠脉造影阴性者30例为正常对照(Control)组。其中 ACS组进一步划分为急性心肌梗死(acute myocardial infarction,AMI)组、不稳定心绞痛(unstable angina pectoris,UAP)组。Gensini评分系统对冠脉病变程度评分。ELISA盒测定血浆中的Cox-2、Salusin-a水平。结果:ACS组血浆Cox-2及超敏C反应蛋白(high sensitivity-C reactive protein,hs-CRP)水平明显高于 SAP组和 Control组 [(16.39±3.64) vs. (13.79±1.76)、(13.38±1.98) ng/ml,P=0.001、P=0.000;(5.61±6.77) vs. (1.50±1.48)、(1.35±1.49) mg/L,P=0.003、P=0.000]。AMI组血浆 Cox-2及超敏C反应蛋白(high sensitivity-C reactive protein,hs-CRP)水平亦高于 UAP组[(18.88±3.97) vs. (15.09±2.70) ng/ml,P=0.028;(9.05±7.92) vs. (3.67±5.18) mg/L,P=0.002]。ACS组及SAP组的血浆Salusin-a水平均低于Control组[(0.13±0.07)、(0.11±0.04) vs. (0.18±0.08) ng/ml,P=0.003、P=0.001],而 ACS组与 SAP组 Salusin-a水平无统计学差异。结论:炎症因子 Cox-2与 hs-CRP能够对ACS危险分层具有预测价值;脂质因子 Salusin-a与冠心病发病密切相关,但并不能反映疾病的严重程度。
英文摘要:
      Objective:To explore the inflammatory factor of Cox-2 and lipid factor of Salusin-a’ s predictive value in the risk stratification of acute coronary syndrome(ACS) and the correlation among it’s main risk factors. Methods:One hundred and ten patients underwent coronary angiography(CAG) were divided into three groups:ACS group(n=61),stable angina pectoris(SAP) group(n=19) and control group(n=30) who had negative results in CAG according to their medical histories and CAG results. ACS group(n=61) was subdivided into acute myocardial infarction(AMI) group and unstable angina pectoris(UAP) group. ACS group was also divided into different groups based on the Gensini scoring system.Plasma levels of Cox-2 and Salusin-a were measured by ELISA. Results:Plasma levels of Cox-2 and high sensitivity-C reactive protein(hs-CRP) were significantly higher in ACS group than in SAP group and control group((16.39±3.64) ng/ml vs. (13.79±1.76) ng/ml and (13.38±1.98) ng/ml,P=0.001,P=0.000;((5.61±6.77) mg/L vs. (1.50±1.48) and (1.35±1.49) mg/L,P=0.003,P=0.000). Plasma levels of Cox-2 and hs-CRP were significantly higher in AMI group than in UAP group ((18.88±3.97) ng/ml vs. (15.09±2.70) ng/ml,P=0.028;(9.05±7.92) mg/L vs. (3.67±5.18) mg/L,P=0.002). Though Salusin-a level was lower in ACS group and SAP group than in control group((0.13±0.07) ng/ml and (0.11±0.04) ng/ml vs. (0.18±0.08) ng/ml,P=0.003,P=0.001),it was not significantly different between ACS group and SAP group. Conclusions:Inflammatory factor of Cox-2 and hs-CRP have predictive value in the risk stratification of ACS. Lipid factor of Salisin-a is associated with coronary heart disease,but could not necessarily reflect the severity of the disease.
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