引用本文:吕 娟,宋 鑫.miR-130a/b与肿瘤关系的研究进展[J].重庆医科大学学报,2014,38(3):273~277
miR-130a/b与肿瘤关系的研究进展
Progress in the relationship between miR-130a/b and tumor
DOI:
中文关键词:  miR-130a  miR-130b  肿瘤  功能  靶基因
英文关键词:miR-130a  miR-130b  tumor  function  target genes
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作者单位
吕 娟,宋 鑫 昆明医科大学第三附属医院肿瘤生物治疗中心昆明 650118 
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中文摘要:
      目的:总结国内外miR-130a和miR-130b在肿瘤学领域研究的现状。方法:应用PubMed和中国知网数据库检索系统,以“microRNA、miR-130a、miR-130b和肿瘤”等为关键词,联合检索1993-01—2013-12的相关文献。纳入标准:1)microRNA在肿瘤研究中的新进展;2)miR-130a;3)miR-130b;4)肿瘤。根据纳入标准,符合分析的文献47篇。结果:miR-130a和miR-130b是高度同源的microRNA,通过干扰靶mRNA转录或降解靶基因来调控基因表达,它们在不同的肿瘤中差异表达,并在多种肿瘤细胞的增殖、凋亡、转移和肿瘤耐药方面发挥着重要作用。结论:miR-130a/b在肿瘤发生发展中发挥促癌或抑癌的作用,其在肿瘤耐药方面的研究可以为多重耐药的患者提供新的视角。
英文摘要:
      Objective:To review the progress in the relationship between miR-130,miR-130b and tumor. Methods:Literatures pub-lished between January 1993 to December 2013 in Pubmed and CNKI data-base were searched using ‘microRNA,miR-130a,miR-130b and tumor’ as key words. Retrieval criteria:1)the progress of microRNA in tumor research;2)miR-130a;3)miR-130b;4) tumor. A total of 47 articles were included. Results:miR-130a and miR-130b were two highly homologous microRNAs,which regulated the expression of target genes through translational repression or mRNA degradation. The aberrant expression of miR-130a/b were involved in proliferation,apoptosis,metastasis and drug resistance of various tumor cells. Conclusions:miR-130a/b can act as oncogenes or tumor suppressors relating to the initiation and development of tumors,which may provide new perspective for the treatment of mul-tidrug resistance in tumors.
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