引用本文:杨得志1,唐石伏2,柳满然2.结直肠癌循环血游离miRs分子诊断标志物研究进展[J].重庆医科大学学报,2014,38(3):277~280
结直肠癌循环血游离miRs分子诊断标志物研究进展
Advance of colorectal cancer’ molecular diagnostic biomarkers-circulating free miRs
DOI:
中文关键词:  结直肠癌  循环血游离miRs  诊断价值
英文关键词:colorectal cancer  circulating free miRs  diagnostic value
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作者单位
杨得志1,唐石伏2,柳满然2 1. 广西中医药大学第三附属医院病理科柳州 5450012. 重庆医科大学临床检验诊断学教育部重点实验室重庆 400016 
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中文摘要:
      微小RNAs(microRNAs,miRs)是一类非编码小分子单链RNA,主要在翻译水平负性调控基因表达。近年来研究发现,循环血游离miRs对结直肠癌(colorectal cancer,CRC)具有潜在的诊断作用。CRC患者具有特异性的循环血游离miRs表达谱,其中,miR-18a、miR-21、miR-29a和miR-92a等miRs均具有潜在的CRC诊断价值,而miR-7具有潜在的CRC早期诊断价值。这些研究结果表明,循环血游离miRs有可能成为新的CRC分子诊断标志物。
英文摘要:
      MicroRNAs(miRs) are noncoding small RNAs,being single strand in the mature form,which negatively regulate gene expression at the translational level. Recent studies have showed that circulating free miRs will probably play an important role in diagnosing colorectal cancer(CRC). CRC patients have a specific expression profile of circulating free miRs,among which miR-18a,miR-21,miR-29a,and miR-92a have a potential di-agnostic value for CRC respectively. Moreover,miR-7 may distinguish patients of CRC at early stage from healthy individuals. These significant findings suggest that circulating free miRs are potential molecular diagnostic biomarkers of CRC.
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