引用本文:傅应亚,黎友伦.JNK信号通路与细胞凋亡[J].重庆医科大学学报,2014,38(3):281~283
JNK信号通路与细胞凋亡
Relationship between JNK signal pathway and cell apoptosis
DOI:
中文关键词:  c-Jun氨基末端激酶信号通路  肿瘤耐药  细胞凋亡
英文关键词:c-Jun N-terminal kinases signal pathway  tumor resistance  cell apoptosis
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傅应亚,黎友伦 重庆医科大学附属第一医院呼吸内科重庆 400016 
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中文摘要:
      肿瘤耐药的分子机制很复杂,包括染色体和基因表达的异常,细胞内药物蓄积减少,DNA损伤修复功能增强,细胞解毒功能增强,凋亡信号传导异常、凋亡抑制因子表达异常等。其中凋亡及生存相关的细胞信号通路是目前研究的热点。丝裂原活化蛋白激酶(mitogen activated-protein kinase,MAPK)信号通路是其中一条引人注目的通路。本文综述了MAPK信号通路中的一条重要通路c-Jun氨基末端激酶(c-Jun N-terminal kinases,JNK)信号通路,JNK信号通路与细胞凋亡的关系,以及其与肿瘤耐药相关的研究。
英文摘要:
      Molecular mechanism of tumor resistance is very complex including abnormality of chromosome and gene expression,decrease of intracellular drug accumulation,enhancement of DNA damage and repair function,increase of cell detoxification function,disturbance of apoptosis signal-transduction and abnormality of apoptosis inhibitor. Among them,apoptosis and survival related cell signal pathways are the hotspots now. p38 mitogen-activated protein kinase(MAPK) signal pathway is one of the hotspots. One of the important MAPK signal pathways is JNK signal pathway. This review summarized the relationship between JNK and cell apoptosis as well as the function of JNK in tumor resistance.
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