引用本文:唐 俐1,何密斯1,郑维萍2,陈 黎2,李 昱3.血红素加氧酶1.2在髓母细胞瘤中的表达及意义[J].重庆医科大学学报,2014,38(3):337~340
血红素加氧酶1.2在髓母细胞瘤中的表达及意义
Expression and significance of HO-1 and HO-2 in medulloblastoma
DOI:
中文关键词:  血红素加氧酶  髓母细胞瘤  免疫组化
英文关键词:heme oxygenase  medulloblastoma  immunohistochemistry
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唐 俐1,何密斯1,郑维萍2,陈 黎2,李 昱3 重庆医科大学基础医学院1. 病理生理学教研室2. 实验教学管理中心3. 病理学教研室重庆 400016 
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中文摘要:
      目的:探讨血红素加氧酶(heme oxygenase,HO)-1和HO-2在髓母细胞瘤(medulloblastoma,MB)中的表达及意义。方法:采用SP免疫组织化学法检测41例MB组织和23例对照脑组织标本中HO-1和HO-2的表达,分析HO-1和HO-2的表达相关性及其与MB的临床特征(性别、年龄、病理类型和肿瘤部位)之间的关系。结果:在41例MB中,HO-1和HO-2的阳性表达率分别为78.0%(32/41)和73.2%(30/41),高于对照脑组织(P=0.002、0.001),且二者在MB中的表达呈正相关(rs=0.477,P=0.009);HO-1和HO-2在MB中的表达与患者的性别、年龄和肿瘤部位等临床特征均无相关性,差异无统计学意义(HO-1:?字2=0.118、0.000、2.903,P=0.732、1.000、0.424;HO-2:?字2=2.737、1.191、1.169,P=0.098、0.662、0.945),但HO-1和HO-2在不同组织病理学类型的MB中的表达具有统计学差异(HO-1:?字2=12.570,P=0.002;HO-2:?字2=6.677,P=0.044)。结论:HO-1和HO-2的高表达在MB的生长中发挥重要作用。HO-1和HO-2的表达与MB的组织病理学分型密切相关,提示HO-1和HO-2可作为评估患者病情和预后的新指标及治疗新靶点。
英文摘要:
      Objective:To investigate the expression and clinical values of heme oxygenase(HO)-1 and HO-2 in medulloblastoma. Methods:Expression of HO-1 and HO-2 in 41 cases of medulloblastoma and 23 cases of control brain tissues was determined by im-munohistochemical assay with SP staining. Relationship between HO-1 and HO-2 expression as well as relationship between HO-1 and HO-2 expression and clinical features(sex,age,histopathology and tumor location) were analyzed with corresponding statistical meth-ods. Results:Expression rates of HO-1 and HO-2 in 41 cases of medulloblastoma were 78.0%(32/41) and 73.2%(30/41) respective-ly,significantly higher than those in control brain tissue(P=0.002,0.001). Expression of HO-1 was positively related with expression of HO-2(rs=0.477,P=0.009). There was no difference in gender,age and tumor location between negative and positive of HO-1 and HO-2 groups(HO-1:?字2=0.118,0.000,2.903;P=0.732,1.000,0.424;HO-2:?字2=2.737,1.191,1.169,P=0.098,0.662,0.945). However,expression of HO-1 and HO-2 showed significant difference in medulloblastoma with different histopathology types(HO-1: ?字2=12.570,P=0.002;HO-2:?字2=6.677,P=0.044). Conclusions:High expression of HO-1 and HO-2 play an important role in medulloblastoma growth. Futhermore,expression of HO-1 and HO-2 is significantly associated with histopathology of medulloblastoma,indicating that HO-1 and HO-2 may be used as new marker for patient’s state,prognosis and therapeutic target.
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